中文摘要：

通过羧甲基壳聚糖接枝二甲基十八烷基环氧丙基氯化铵，合成水油两溶性的羧甲基壳聚糖十八烷基季铵盐（OQCMC）；并将其作为乳化剂与乳酸-羟基乙酸（PLGA）和羟乙基纤维素（HEC）复合，利用溶剂挥发法，构建一种多功能的药物载体缓释系统，并尝试包裹脂溶性药物盐酸米诺环素．利用透射电子显微镜（TEM），激光光散射仪，Zeta电位仪，FTIR，1HNMR等对OQCMC及载药微球进行表征，并进行药物的体外释放实验．结果表明：OQCMC可作为一种优良的乳化剂对PLGA微球进行修饰；并可使复合微球体系带正电，在提高微球载药率（9．4％）的同时减小微球粒径[（166．4±0．8）nm]；复合微球体系对盐酸米诺环素具有较好的物理包裹能力，并有长效缓释作用（PBS，pH=7．9）．

英文摘要：

Octadecyl quaternized carboxymethyl chitosan （OQCMC） was synthesized through carboxymethyl chitosan grafting with glycidyl octadecyl dimethylammonium chloride. By a solvent evaporation method, the drug delivery system was prepared based on poly（lactic-co-glycolic acid） （PLGA） block copolymers, hydroxyethyl cellulose and OQCMC, which was tried to load minocycline hydrochloride. The microspheres were characterized by transmission electron microscopy （TEM）, quasielastic laser light scattering with a Malvern Zetaslzer, 1H NMR and PTIR. The results showed that the complex delivery system was good to load the minocycline hydrochloride and could provide long-term release behaviour through drug release experiment in vitro. The drug loading efficiency of minocycline hydrochloride could reach 9.4% by using the polymer surfactant OQCMC. It is good to decrease the particle size [（166.4±0.8） nm], increase the Zeta potential and keep the stabilization of the microspheres.