中文摘要：

卵巢早衰是指女性在40岁以前发生无月经,高促性腺激素及低雌激素症状。大部分卵巢早衰无明确病因可循,已知的病因包括遗传因素、常染色体突变、环境损伤及自身免疫性疾病。卵巢早衰危害妇女健康,近年来其发病率有逐年上升的趋势。对诊断卵巢早衰的妇女需处理好三方面的内容：患者心理健康的影响、不育和由于卵巢衰竭所致雌激素缺乏的短期和长期症状。

英文摘要：

Premature ovarian failure（POF）is defined as the occurrence of amenorrhea,hypergonadotropinemia and estrogen deficiency in women under the age of 40 years.In the majority of cases,the etiology is unknown,but known causes include hereditary factors,autosomal mutations,environmental insults,autoimmune factors.POF compromise women health.Incidence of POF is ascending year by year。The three critical issues of management in these women are the effect of the diagnosis on the psychological health of the patient,the consequent infertility and the long-and short-term effects of estrogen deficiency arising from ovarian decline.