中文摘要：

为关节的软骨到的 ObjectiveUsing 特马平先生和组织病理学说的分数在关节的 cartilage.MethodsTwenty 上在 subchondral 骨头评估结构的变化的效果 -- 四条雄的猎兔犬狗随机被划分成一个 subchondral 骨头缺点组(n = 12 ) 并且一个骨头水泥组(n = 12 ) 。中间的胫骨的高原和 subchondral 骨头用骨头水泥填满的 subchondral 骨头 defectin 的模型被构造。在所有狗，左膝关节被用作试验性的 sideand 是的右膝假冒的方面。为在中间的胫骨的高原的关节的软骨的 T2 价值在手术后的星期被测量 4， 8， 16，和 24。关节的软骨标本与 hematoxylin 和曙红被染色，并且评估了使用 Mankin score.ResultsThere 是统计上重要的差别(P < 0.05 ) 在在骨头缺点之间的 Mankin 分数，组和水泥在手术后的星期组织 16 和 24。在在骨头缺点组和它的假冒的组之间的 T2 价值有统计上重要的差别(P < 0.05 ) 从星期 8，并且在水泥组和它的假冒的组之间(P < 0.05 ) 从星期 16。在在在手术后的星期的二个试验性的组之间的 T2 价值有重要差别 24 (P < 0.01 ) 。为关节的软骨的 T2 价值断然与 Mankin 分数被相关(= 0.758， P < 0.01 ) 在 subchondral 骨头的 .ConclusionStructural 变化能导致邻近的关节的软骨的退化。在 subchondral 骨头的缺点比 subchondral 骨头充满水泥的引起软骨的更多的严重退化。为有退化的程度的关节的软骨增加的 T2 价值。为关节的软骨的特马平先生图象和 T2 值能显示 earlycartilage 退化。

英文摘要：

Objective Using MR T2-mapping and histopathologic score for articular cartilage to evaluate the effect of structural changes in subchondral bone on articular cartilage. Methods Twenty-four male Beagle dogs were randomly divided into a subchondral bone defect group （n = 12） and a bone cement group （n = 12）. Models of subchondral bone defectin the medial tibial plateau and subchondral bone filled with bone cement were constructed. In all dogs, the left knee joint was used as the experimental sideand the right knee as the sham side. The T2 value for articular cartilage at the medial tibial plateau was measured at postoperative weeks 4, 8, 16, and 24. The articular cartilage specimens were stained with hematoxylin and eosin, and evaluated using the Mankin score. Results There was a statistically significant difference （P 〈 0.05） in Mankin score between the bone defect group and the cement group at postoperative weeks 16 and 24. There was a statistically significant difference in the T2 values between the bone defect group and its sham group （P 〈 0.05） from week 8, and between the cement group and its sham group （P 〈 0.05） from week 16. There was significant difference in T2 values between the two experimental groups at postoperative week 24 （P 〈 0.01）. The T2 value for articular cartilage was positively correlated with the Mankin score （ρ = 0.758, P 〈 0.01）. Conclusion Structural changes in subchondral bone can lead to degeneration of the adjacent articular cartilage. Defects in subchondral bone cause more severe degeneration of cartilage than subchondral bone filled with cement. The T2 value for articular cartilage increases with the extent of degeneration. MR T2-mapping images and the T2 value for articular cartilage can indicate earlycartilage degeneration.