中文摘要：

巨噬细胞在动脉粥样硬化免疫应答中发挥着重要作用,巨噬细胞自噬作为动脉粥样硬化新的参与者也获得普遍共识。巨噬细胞自噬是由溶酶体系统降解胞内受损、变性及衰老的蛋白质与细胞器的过程,基础水平的自噬可保护细胞免受环境刺激影响,对于控制动脉粥样硬化进程具有重要意义,反之过度自噬则导致细胞死亡,斑块失稳。本文拟从炎症、内质网应激以及活性氧类等角度对自噬在动脉粥样硬化中的作用及机制作一综述。

英文摘要：

Macrophages plays crucial roles in atherosclerotic immune responses.Macrophage autophagy plays a significant role in the process of atherosclerosis.The lysosomal system degrades damaged,degenerated,senescent organelles and proteins in the cytoplasm.Normal level of autophagy can protect the cells from environmental stimuli,thus suspend the process of atherosclerosis,while excessive autophagy can lead to cell death and do harm to the stability of the plaque.This review mainly focuses on the mechanism of autophagy in atherosclerosis from the aspects of inflammation,endoplasmic reticulum stress and reactive oxygen species.