中文摘要：

咪喹莫特是一种新型的局部小分子免疫调节物，可以通过与免疫相关细胞表面的Toll样受体结合、促进干扰素-α、肿瘤坏死因子-α、白介素-12等多种前炎症细胞因子的分泌，进而激活天然与获得性免疫反应的方式，发挥抗肿瘤活性。通过上调Fas和／或下调bcl-2表达诱导肿瘤细胞凋亡，可能是咪喹莫特抗皮肤肿瘤的另一重要机制。

英文摘要：

Imiquimod, a new topical small-molecule immune response modifier, has been found to be effective in treating some skin tumors. The underlying mechanism of its anti-skin tumor effects include the activation of innate and acquired immunity through binding with Toll-like receptors and stimulating the secretion of pro-inflammatory cytokines （ such as IFN-α, TNF-α and IL-12 ）, and induction of tumor cells apoptosis by upregulating Fas expression and/or downregulating bcl-2 expression.