中文摘要：

目的探讨全反式维甲酸（ATRA）对糖尿病大鼠足细胞损伤的保护作用。方法24只链脲佐菌素（STZ）诱导的糖尿病大鼠模型，随机分为糖尿病组（DM）和治疗组（T）各12只，另以12只正常大鼠作为对照组（N）。T组给予AⅡ认20mg·kg^-1·d^-1灌胃。于第4、8周末检测各组大鼠尿蛋白定量（24h）、Ccr、肾重／体重、尿中足细胞以及肾脏病理改变。结果DM组尿蛋白定量（24h）、Ccr、肾重／体重、尿中足细胞数[8周时，0．84（0．60—1．50）个／ml]均显著高于同期N组[0．03（0—0．15）个／m1]，而肾小球足细胞数（8周时，11．27±2．15）显著低于同期N组（14．07±2．07），且足细胞足突增宽、融合。T组尿蛋白定量（24h）、Ccr、肾重／体重、尿中足细胞数较同期DM组显著降低[0．46（0．25—0．70）个／d]，且病理改变减轻。结论ATRA可以减少糖尿病大鼠尿足细胞的排泄、降低尿蛋白，对肾脏足细胞损伤具有保护作用。

英文摘要：

Objective To investigate the protective effect of all-trans retinoic acid （ATRA） on podocyte lesion in diabetic rats. Methods Twenty-four rats injected with streptozotocin （STZ） were randomly divided into model（DM） and therapy group（T）. Other 12 normal rats were used as control group （N）. The rats in T group were administrated ATRA at a dosage of 20 mg·kg^-1·d^-1, and animals in other groups were treated with normal saline. 24 h urinary protein, urinary podocyte excretion, and renal pathological alteration were determined after 4 and 8 weeks. Results 24 h urinary protein, ratio of kidney weight to body weight, and urinary podocyte excretion were significantly higher in DM group compared to N group[0.84（0.60-l.50） vs 0.03（0-0.15）cell/ml, P 〈 0.05]. The numbers of glomerular poddocyte were significantly reduced in DM group（ 11.27±2.15 vs 14.07±2.07）. Diabetic rats treated with ATRA （T group） had less urinary podocyte excretion[0.46 （0.25±0.70）cell/ml] and more glomerular podocyte numbers compared to DM group. Conclusions ATRA can decrease the excretion of urinary podocyte and proteinuria. ATRA has a protective effect on podocyte lesion in diabetic rats.