中文摘要：

天然产物作为植物、动物和微生物的次级代谢产物,具有特殊的生理活性.但一些天然产物由于结构特性导致其脂溶性或水溶性较差,生理活性利用率不高,需对其进行结构修饰.通过酶催化的方法对天然产物进行结构修饰更容易获得选择性产物.近年来,离子液体作为绿色反应介质,被应用于酶促反应,其对酶的选择性和活性具有较大影响.综述了离子液体中酶催化天然产物如黄酮、有机酸、糖类、L-抗坏血酸和植物甾醇等结构修饰的研究进展.

英文摘要：

As secondary metabolites of animals,plants and microbes,natural products have special biological activity. But because of the short in the structural characteristics,resulting in their poor solubility in fat or water and lower physiological activity utilization,so it is necessary to modify their structures. Enzymatic method can increase the selectivity of the modification of natural products. As a kind of green reaction media,ionic liquids have great impacts on the selectivity and activity of enzymatic reaction. The present study was to summary the progress on the enzymatic modification of natural products such as flavonoids,organic acids,sugars,L-ascorbic acid and phytosterols in ionic liquids. It is concluded that the ionic liquids used in the enzymatic reaction are selected mainly through the experience,and lack of systematic screening and design synthesis in the present stage.Secondly,ionic liquids are known as green solvents,mainly because of their low vapor pressure,and will not be released into the atmosphere by volatilization. But some ionic liquids degradation cycle is longer,easy to accumulate in soil and water. Therefore,the synthesis of new and low toxicity,biodegradable ionic liquids and their applications in the modification of natural products are the direction of further research.