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中文摘要：
在非水介质中，脂肪酶选择性催化曲克芦乙烯酯与脂肪胺进行酰胺化反应，合成系列N-N基曲克芦丁酰胺类似物．考察了酶源、酶量、反应介质、溶剂含水量、反应时间等因素对曲克芦丁乙烯酯的酰胺化区域选择性的影响．结果表明：反应温度50℃，以吡啶为溶剂、且其含水量小于1％时，lipase LS-10催化活性最高；当酶用量20mg／mL，反应时间21h后，反应基本达到平衡．
英文摘要：
In nonaqueous medium, a series of troxerutin amidation analogues were synthesized by the reaction of vi- nyl-troxerutin esters with fatty amines. The influence parameters including enzyme source, the amount of the enzyme, reactive medium, water content of solvents and reaction time were investigated. The results showed that the amidation occurred regioselectively at vinyl-ester bond. Using pyridine as solvent （water content 〈 1%）, the amidation reaction catalyzed by lipase LS-10 （20 mg/mL） reached plateau after 21 h at 50 ℃.
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