中文摘要：

目的探讨经直肠超声引导下前列腺穿刺活检诊断前列腺癌的临床价值。方法检索PubMed、Emhase、cochrane Lihrary、SCI、中国生物医学文献数据库、中国期刊全文数据库、中文科技期刊数据库、万方数据库等数据库，检索时间截至2015年1月。由3位研究者根据纳入与排除标准独立筛选文献、提取资料和评价质量，文献筛选严格按照纳入和排除标准，纳入研究的质量评估采用诊断性试验质量评价（QuADAs）评分量表，灵敏度合并、特异度合并、诊断比值比（DOR）及其95％CI、综合受试者工作特征（SROC）曲线下面积（Auc）和Q＊指数均采用Meta-Disc 1．4软件进行统计学分析。结果最终纳入5项基于中国人群的研究。荟萃结果显示：经直肠超声引导下前列腺穿刺活检诊断前列腺癌的灵敏度合并为0．84（95％CI为0．79～0．89），特异度合并为0．98（95％CI为0．94～0．99），DOR合并为170．95（95％CI为55.68～524.84），SROC AuC为0．9625，Q＊指数为0．9082。结论直肠超声引导下前列腺穿刺活检早期诊断前列腺癌具有很高的临床价值。

英文摘要：

Objective To explore the diagnostic value of transrectal ultrasound-guided ＂6＋X＂ points biopsy in prostate cancer. Methods All eligible databases were searched using the keywords, and the literature was evaluated by QUADAS. Statistical analysis was performed using Meta-Disc 1.4. Results Five studies satisfied the inclusion critcria. The transreetal ultrasound-guided ＂6＋X＂ points biopsy in the diagnosis of prostate cancer exhibited the following characteristics： sensitivity, 0.84 （95%CI, 0.79-0.89 ）; specificity, 0.98 （95%CI, 0.94-0.99）; positive likelihood ratio, 26.06 （95%CI, 2.87-236.68）; negative likelihood ratio, 0.21 （95%CI, 0. 16-0.28）; and diagnostic odds ratio, 170.95 （95%C1, 55.68-524.84）. The summary receiver operating characteristic curve indicated that the maximum joint sensitivity and specificity （Q＊-value） were 0.9625, and the Q index value was 0.9082. Conclusion Transrectal ultrasonography combined with ＂6＋X＂ method had high clinical value in the early diagnosis of prostate cancer.