中文摘要：

CD4+CD25+ T 房间在 modulating 免疫者反应起一个主要作用，但是很少报告被出版了关于血吸虫病。这里，我们在怒气和感染血吸虫的老鼠的 mes 伤寒淋巴节点在 CD4+CD25+ T 房间人口调查了变化日本嗯。在全部的 CD4+ T 房间的 CD4+CD25+ T 房间的比例被流动 cytometry 分析。CD25 和 Foxp3 表示被即时量的聚合酶链反应测量。CD4+CD25+ T 房间的镇压活动被检测由在 splenocytes 的 vitro 增长。证据证明 CD4+CD25+ T 房间的百分比 3 个星期与控制一样感染以后。在感染的尖锐阶段，百分比显著地减少了。在感染的长期的阶段，然而，它反弹到正常层次或甚至更高。CD25 和 Foxp3 的表示与感染进步一起显示出渐渐的增加。在 vitro，实验也显示出 CD4+CD25+ T 房间的强壮的镇压效果，在长期的阶段期间孤立，在 CD25- splenocytes 的增长上。这是 CD4+CD25+ T 房间人口的动力学在感染的老鼠被表明的第一次血吸虫病。在结论，我们的数据显示 CD4+CD25+ 房间可能在 S 期间涉及有免疫力的调整。日本嗯感染，它提高 immuno-downregulation 和再感染的机制的当前的知识在血吸虫病。

英文摘要：

CD4^＋CD25^＋ T cells play a major role in modulating immune response, but few reports have been published about schistosomiasis. Here, we investigated the changes in CD4^＋CD25^＋ T cell populations in spleens and mesenteric lymph nodes of mice infected with Schistosoma japonicum. The proportions of CD4^＋CD25^＋ T cells in total CD4^＋ T cells were analyzed by flow cytometry. CD25 and Foxp3 expression was measured by real-time quantitative polymerase chain reaction. The suppressive activities of CD4^＋CD25^＋ T cells were detected by in vitro proliferation of splenocytes. Evidence showed that the percentage of CD4^＋CD25^＋ T cells was the same as controls 3 weeks post-infection. At the acute stage of infection, the percentage decreased significantly. However, at the chronic stage of infection, it rebounded to normal levels or even higher. The expression of the CD25 and Foxp3 showed gradual increase along with the infection progress. In vitro experiment also showed the strong suppressive effect of CD4^＋CD25^＋ T cells, isolated during the chronic stage, on proliferation of the CD25^- splenocytes. This is the first time that the dynamics of CD4^＋CD25^＋ T cell populations was demonstrated in mice infected with schistosomiasis. In conclusion, our data indicated that CD4^＋CD25^＋ cells might be involved in the immune modulation during S. japonicum infection, which enhances current knowledge of the mechanisms of the immuno-downregulation and re-infection in schistosomiasis.