中文摘要：

用三氯化铝催化六氯三聚膦腈开环聚合制得线性聚二氯膦腈（PDCP），通过PDCP磷原子上的亲核取代反应，合成了新的水溶性高分子聚[（甲氧基乙氧基乙氧基）。（乙氧基吡咯烷酮）1.0]膦腈（P3），用^31PNMR，^1H NMR，^13C NMR和IR对其结构进行了确证，用DSC测定了其玻璃化转变温度Tg和熔融温度Tm，用蒸汽压渗透法（VPO）测定了其数均分子量．改进了聚二（乙氧基吡咯烷酮）膦腈（P2）的合成方法．体外降解实验表明，P3具有和P2类似的pH响应性降解行为，降解速率在pH=5．0时最快，而在pH=7．4和8．0时较慢．P3在所测试的3个pH缓冲溶液中均比P2降解慢．用^31P NMR、薄层色谱（TLC）和滴定法对降解产物进行了检测，初步推断了P3在不同pH介质中的水解机理，其在pH=5．0的缓冲溶液中的降解，除侧链断裂外，聚膦腈的骨架也裂解；而在pH=7．4和8．0时的降解仅为侧链的断裂．用噻唑蓝（MTT）比色法进行的体外细胞毒性评价实验表明，P3及其在pH=5．0的缓冲溶液中降解49d后的产物均对细胞表现出了很好的生物相容性，而且其降解产物在浓度为800μg／mL时还表现出一定的促进细胞增殖作用．

英文摘要：

Polydichlophosphazene （PDCP） was prepared by the ring-opening polymerization of hexachlorocyclotriphosphazene in the presence of 2%AlCl3. A new mixed substituent poly （organophosphazene） bearing 2-（2-oxy-l-pyrrolidiny） ethoxy and methoxyethoxyethoxy side groups was synthesized via the macromolecular substitution reactions of poly （dichlorophosphazene） with the sodium salt of 1 - （2-hydroxyethyl） -2-pyrrolidone and sodium methoxyethoxyethoxide. Its structure was verified by ^31p NMR, ^1H NMR, ^13C NMR, IR and DSC. Its molecular weight was determined by vapor pressure osmometry（VPO）. 18-Crown-6 was used in the synthesis of poly[ di （2-oxy-l-pyrrolidiny）ethoxyphophazene ] （PYRP） as phase transfer catalysis in order to improve its synthetic method. The new polymer and PYRP were water-soluble and their in vitro degradation behavior was studied at varied pH conditions. The results indicate that the degradation of poly （ organophosphazenes） with （2-oxy-l-pyrrolidiny）ethoxy side groups is dependent on pH of the buffer solution. The rate of hydrolysis was more rapid at pH = 5.0 than at pH = 7.4 and pH = 8.0. It was shown that addition of methoxyethoxyethoxy side group to PYRP structure resulted in a decrease in the rate of hydrolysis. The hydrolysis products of the poly（organophosphazenes） were analyzed by ^31P NMR, thin layer chromatography（TLC ） and titration methods. A hydrolysis pathway of the new polymer in buffer solutions with pH = 5.0, 7.4 and 8. 0 was proposed. The degradation of the polymers at pH =5.0 involved a hydrolytic cleavage of （2-oxy-l-pyrrolidiny） ethoxy from the chain followed by the degradation of the phosphorus-nitrogen backbone to form phosphate and ammonium. However, the degradation of the polymers at pH = 7.4 and pH = 8.0 was only cleavage of the side group. The MTT test for the new polymer and its hydrolysis products at pH = 5.0 in HepG2 cell revealed that an increase in polymer concentration from 1.3 to 800 μg,/mL was not harmful for the cell