中文摘要：

采用溶胶-凝胶法合成粒径为3nm的TiO2颗粒，通过尾静脉注射到小鼠体内，在不同时间点剖取重要脏器，并用电感耦合等离子体-质谱法（ICP-MS）测量各个器官内TiO2的含量。结果显示，尾静脉注射进入小鼠体内的TiO2，很快随血流分布到全身各脏器，滞留在体内的TiO2主要集中在肺、肝、脾三脏，每克组织的摄取量（％ID／g）分别在6h、1h、1h达到最大值141.73％、25.55％、18.07％。实验还发现，对照组小鼠脑中面的含量高于血液，静脉注射3nmTiO2后，小鼠脑中曩的含量显著增加，在实验的各个时间点（除0.5h），实验组小鼠脑中面的含量都比血液高。结果表明纳米TiO：颗粒的脑毒性研究可能成为其生物效应研究的重点。

英文摘要：

In this work, TiO2 nanoparticles of 3 nm in size were synthesized by sol-gel technique and injected intravenously into mice. The organs were collected at 0.5, 1, 3, 6, 24 and 48 h after injection. Ti content in the organs was detected by inductively coupled plasma mass spectrometry （ICP-MS）. The results indicated that injected TiO2 nanoparticles were translocated into the organs via bloodstream immediately after injection, and deposited mostly in lung, liver and spleen. The TiO2 uptake （%ID/g） in the three organs reached the peak value of 141.73%, 25.55%, and 18.07% at 6 h, 1 h and 1 h after injection, respectively. The results also showed that there was significant amount of Ti in the brains of the control, and the brain Ti content increased markedly after injection. At 1, 3, 6, 24 and 48 h after injection the brain Ti content was higher than that in blood. The experiment indicated that its toxicity on brain would be the emphasis of biological impact study of nano TiO2.