天然产物广泛地存在于植物体内,是药物、食品添加剂和新型生物燃料等开发的主要来源,具有重要的商业价值,该类化合物也一直是合成生物学研究的热点之一。随着研究的深入,近年来以植物为底盘的天然产物研究日益兴起。本文中,笔者综述了近年来以植物为底盘的天然产物合成生物学研究的进展,包括该类代谢物代谢途径的解析、以植物为底盘的遗传操作技术和方法等,为相关研究者提供参考。
Natural products are widely produced in plants and become major source of pharmaceut icals, aromatics and potent ial next-generation biofuels,wi th great commercial value.These compounds have also been the hotspots of synthetic biology. With deeper invest igat ion,plant chassis have been increasingly appl ied to natural product biosynthesis research. In this paper,we reviewed the recent advances and achievements of synthetic biology based on plant chassis,including metabolic pathway elucidat ion,genetic manipulation technology and methods.