中文摘要：

目的通过对女性青少年特发性脊柱侧凸患者的髂软骨进行组织计量学研究来评价生长潜能预测因素的价值。方法收集女性特发性脊柱侧凸患者的髂软骨标本，并测量静止层高度以明确患者的生长潜能。将患者的年龄，月经来潮时间，腕骨骨龄，Risser征及肋骨小头、肱骨近端、椎体环、坐骨结节的次发骨骺融合情况按照相应方法进行分级，比较各级间的组织学分级及静止层高度，并将各个参数分级与髂软骨的静止层高度作相关性分析以评价其预测价值。结果共收集有效标本53份。平均年龄14．0岁。组织学分级0级者11例，Ⅰ级者9例，Ⅱ级15例，Ⅲ级18例。静止层高度0-3．70mm，平均（1．61±1．02）mm。统计学分析结果显示腕骨骨龄〉16岁、年龄〉16岁、月经来潮2．5年以上、Risser征5级、坐骨结节或肱骨近端次发骨骺融合的患者均没有明显的增殖活性和生长潜能。本研究评价的参数与髂软骨静止层高度均有良好的负相关性，其中负相关性最好的是腕骨骨龄。结论年龄、月经来潮时间和部分影像学参数可有效地预测生长潜能，其中腕骨骨龄的价值最高。腕骨骨龄〉16岁、年龄〉16岁、月经来潮2．5年以上、Risser征5级以及坐骨结节或肱骨近端次发骨骺融合提示生长基本停止。

英文摘要：

Objective To evaluate the value of growth potentiality predictors in girls with adolescent idiopathic scoliosis （AIS） by histomorphology studying on iliac cartilage. Methods Iliac cartilages were harvested during posterior surgery from AIS girls. The histological grading of the proliferating activity of the iliac cartilage was observed and the height of the resting layer was measure under the microscope. Parameters included chronologic age, menarche status, Risser grade, wrist bone age and the fusion status of proximal humerus, rib head, vertebral ring epiphysis, ischial apophyses were recorded. Every parameter was divided into different group and the histological grades and resting layer height were compared. The correlation analysis was taken between the radiological parameters and the resting layer height. Results The specimens of 53 AIS patients with an average age 14.0 years were stained successfully. Eleven cases divided into histological grade 0, 9 in grade Ⅰ , 15 in grade Ⅱ and 18 in gradeⅢ. The average resting layer height was 1.61 ±1.02 mm. Growth potentiality was not found when wrist bone age or chronic age was over 16 years, 2.5-year post menarche, fusion of iliac crest apophysis, proximal humerus growth plate or the apophysis of ischial tuberosity. The significant negative correlations were found between the parameters and the resting layer height in all the predictors. Wrist bone age showed the most significant negative correlation （P〈 0.01）. Conclusion The chronologic age, menarche age and most of these radiological growth potentiality predictors show significant negative correlations with resting layer height, while the wrist bone age show highest value. Growth potentiality is not found in patients who are over 16y of wrist bone age or chronologic age; 2.5-year post menarche, fusion of iliac crest apophysis, proximal humerus growth plate or the apophysis of ischial tuberosity. Low growth potentiality can be found after the fusion of vertebral ring and rib head.