中文摘要：

10-(4-Formylphenyl )-5,15-bis(pentafluorophenyl)corrole 1 并且它的镓建筑群 1-Ga 被用来在肝癌症(BEL-7402 ) 调查他们的 photocytotoxicity，肺癌症(A549 ) 和颈的癌症(Siha， Hela ) 房间线。在所有测试肿瘤房间之中， Siha 肿瘤房间对光力学的治疗(太平洋夏季时间) 最敏感在 1 的治疗和 1-Ga。1 的太平洋夏季时间 IC ₅₀ 和向 Siha 肿瘤房间的 1-Ga 分别地到达 1.3 和 0.8  µmol/L，它比 cisplatin 的高是 10 褶层。1 并且没有搬运人蛋白质的帮助， 1-Ga 可能顺利越过肿瘤房间膜过去，并且在肿瘤的细胞质主要局部性房间。在太平洋夏季时间治疗以后，增加的细胞内部的反应的氧种类(ROS ) 水平和 mitochondrial 膜潜力显著地减少了，它将最后导致肿瘤房间的 apoptosis。

英文摘要：

10-（4-Formylphenyl）-5,15-bis（pentafluorophenyl）corrole 1 and its gallium complex 1-Ga were used to investigate their photocytotoxicity in liver cancer （BEL-7402）, lung cancer （A549） and cervical cancer （Siha, Hela） cell lines. Among all the tested tumor cells, Siha tumor cells were the most sensitive to photodynamic therapy （PDT） treatment by 1 and 1-Ga. PDT IC50 of 1 and 1-Ga toward Siha tumor cell reaches 1.3 and 0.8 gmol/L respectively, which is 10-fold higher than that of cisplatin. 1 and 1-Ga might pass across the tumor cell membrane smoothly without the help of carrier protein, and mainly localized in the cytoplasm of tumor cell. After PDT treatment, the intracellular reactive oxygen species （ROS） level increased and the mitochondrial membrane potential decreased significantly, which would finally result in the apoptosis of tumor cells.