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氧化应激与高血压发病机制研究
  • ISSN号:1672-6839
  • 期刊名称:中医学报
  • 时间:2015.1.1
  • 页码:101-104
  • 分类:R255.3[医药卫生—中医内科学;医药卫生—中医学]
  • 作者机构:[1]天津中医药大学,天津300193, [2]天津医科大学第二附属医院,天津300381, [3]天津中医药大学第一附属医院,天津300193, [4]国家中医药管理局针刺量效关系三级实验室天津市针灸学重点实验室天津市针灸研究所国家中医药管理局脑病针刺疗法重点实验室,天津300193
  • 相关基金:国家自然科学基金(81202738);天津市应用基础与前沿技术研究计划(15JCZDJC36700)
  • 相关项目:基于NO-cGMP-PKG信号转导通路的针刺降压的抗氧化应激机制研究
中文摘要:

目的:研究耳针治疗原发性高血压的临床疗效、安全性及应用规律。方法:检索相关耳针治疗原发性高血压的随机或半随机试验,采用NoteExpress_3.1.0.6915_软件查重,运用Revman5.2软件进行Meta分析。结果:最终纳入16篇文献,样本总量为1535例。所纳文献近5年的占81.25%,年限较近;耳针治疗原发性高血压不良作用较少;耳针配合药物可大大提高降压的总有效率和增加降收缩压的效应;耳针单独降收缩压的效应优于药物;耳针治疗原发性高血压的主穴依次选用神门、内分泌、心、降压沟、肝、肾,其他配穴可辨证选用。操作时间和疗程尚未发现影响规律。结论:耳针治疗原发性高血压安全性较高;临床具有一定疗效,尤其耳针单独用于降收缩压和耳针配合药物降低总体血压方面。但纳入研究质量存在一定局限性,需更多更合格的随机对照试验验证。

英文摘要:

Objective:To evaluate the curative effect, safety and application criterions of the auricular acupuncture for essential hy- pertension. Methods: We included all the relevant Randomized Controlled Trials(RCTs) and quasi-RCTs of auricular acupuncture for essential hypertension, using NoteExpress 3.1.0. 6915 rechecking software, using Revman 5.2 software for Meta analysis. Re- sults:1535 patients being included 16 papers met the enrolled criteria. Auricular acupuncture treatment of essential hypertension with less adverse effects; Auricular acupuncturecombine with drugs, it may improve the total effective rate, increase the effects of lower systolic blood pressure(SBP) ;Auricular acupuncturealone is better than drugs reduced systolic blood pressure; Auricular acu- punctureforessential hypertension of main point in turn choose Shenmen, Endocrine, heart, Jiangyagou, liver, kidney, others could be selected by syndrome differentiation. Operating time and treatment have been found without significant difference. Conclusion: The auricular acupuncturefor essential hypertension was high security ; and has a certain curative effect, especially auricular acupunc- ture separately for systolic blood pressure, and auricular acupuncture combine with drugs to lower blood pressure as a whole. Butthere are still a certain limitations, it is necessary to perform more RCTs of high quality inthe future.

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