中文摘要：

目的研究没食子酸（gallic acid）对谷氨酸钠诱导的肥胖小鼠的降脂作用。方法新生乳鼠皮下注射3 mg/（g·d）谷氨酸钠建立肥胖模型,模型建立后将小鼠分为正常对照组、模型组、阳性对照组[辛伐他汀30 mg/（kg·d）]、没食子酸高剂量组[400 mg/（kg·d）]和没食子酸低剂量组[200 mg/（kg·d）]。连续给药10周,于末次给药后禁食不禁水12 h,摘眼球取血,摘取脏器及脂肪,测定脏器指数和脂肪指数。用试剂盒测定血清和肝脏中总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）含有量,测定血清瘦素水平,肝脏超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）酶活力和丙二醛（MDA）水平。结果与正常对照组相比,模型组小鼠体质量及脂肪明显增加,血清及肝脏中TC、TG、LDL-C含有量明显升高,血清中瘦素水平明显降低,肝脏中SOD、GSH-Px水平明显降低,MDA水平明显升高。与模型组相比,没食子酸组小鼠体质量及脂肪明显减少,血清及肝脏中TC、TG含有量明显降低,肝脏中SOD、GSH-Px水平明显升高,MDA水平明显降低。结论没食子酸能显著降低谷氨酸钠诱导的肥胖小鼠的血脂水平。

英文摘要：

AIM To study lipid-lowering effects of gallic acid on glutamate-induced obesity mice.METHODS The obese model was established through subcutaneous injection of 3mg/（g·d） sodium glutamate into neonatal mice.After the model was established,the mice were divided into normal control group,model group,positive control group [simvastatin 30 mg/（kg · d） ],high-,and low-dose group of gallic acid [400,200 mg/（kg·d） ],and were intragastrically administered for ten weeks.Mice in each group after the last administration were fasted for 12 h except water.Blood was sampled from mouse eyes.The organs and adipose were obtained to determine the organ index and fat index.The levels of HDL-C,TG,LDL-C and TC in serum and liver were determined by using the corresponding reagent kit,and the serum leptin level was determined by ELISA kit and simultaneous determination of SOD,GSH-Px and MDA levels in liver.RESULTS Compared with the normal control group,the body weight and fat weight significantly increased in the model group;the levels of TC,TG and LDL-C in serum and liver significantly increased;the serum leptin level significantly reduced;the activity levels of SOD and GSH-Px in the liver significantly reduced;and the level of MDA significantly increased.Compared with the model control group,the body weight and fat weight significantly reduced in the gallic acid group mice and the levels of TC and TG significantly reduced in the serum and liver;SOD and GSH-Px levels significantly increased,MDA level significantly decreased in the liver.CONCLUSION Gallic acid can significantly reduce the blood lipid level of glutamate-induced obese mice.