中文摘要：

以CaH2为缚酸剂，DMF为溶剂，金鸡纳生物碱通过3，6-二氯哒嗪或1，4-二氯-2，3-二氮杂萘桥连，高产率地合成了用作手性配体的13个金鸡纳生物碱衍生物，其结构经NMR确证。

英文摘要：

Thirteen cinchona alkaloid derivatives as chiral ligand were synthesized from cinchona alkaloid using 3,6-dichloro-pyridazine or 1,4-dichloro-2,3-phthalazone as bridged reagent in the presence of CaH2 in DMF under mild condition. The structures were confirmed by NMR.