中文摘要：

目的 研究电针对不同月龄APP/PS1转基因小鼠行为学的影响,探讨电针治疗阿尔兹海默病（Alzheimer＆#39;s disease,AD）的最佳干预时间.方法 选择4、6、9月龄APP/PS1双转基因小鼠各20只,随机分为模型组、电针组,以相同月龄C57BL/6野生鼠各10只作为对照组;电针治疗6星期后,采用Morris水迷宫进行空间记忆行为学测试,观察各月龄各组行为学的变化.结果 5月龄各组组间比较差异均无统计学意义（P〉0.05）,时间因素（day）具有统计学意义（P〈0.01）;7月龄各组组间、时间因素及交互作用比较均具有显著性差异（P〈0.01）;10月龄各组组间、时间因素、交互作用比较差异均有统计学意义（P〈0.05）.各月龄各组空间探索实验穿越平台次数及平台象限游泳距离比较,差异有统计学意义（P〈0.05）.结论 电针可以改善APP/PS1双转基因鼠的学习记忆能力,6~7月龄可能是电针早期干预AD的最佳治疗接入点,但仍需进一步实验机制研究讨论.

英文摘要：

Objective To study the effect of electroacupuncture on the behavior of APP/PS1 transgenic mice of different age, and to explore the optimal intervention time of electroacupuncture in treating Alzheimer＆#39;s disease （AD）. Method APP/PS1 double-transgenic mice of 4 months, 6 months and 9 months old, 20 in each age group, were randomized into a model group and an electroacupuncture group, and ten C57BL/6 wild-type mice were taken as a control group; after 6-week electroacupuncture treatment, the Morris water maze was adopted for spatial memory and behavioral test, and the changes of behavior in each group were observed.Result Of the 5-month-old mice, there were no significant between-group differences （P〉0.05）, while the time factor （day） produced a statistical significance （P〈0.01）; of the 7-month-old mice, there were significant differences considering the different groups, time factor and interaction （P〈0.01）; of the 10-month-old mice, there were significant differences considering the different groups, time factor and interaction （P〈0.05）. The spatial probe test showed that there were significant between-group differences in comparing the platform crossings and swimming distance in platform quadrant in each age group （P〈0.05）.Conclusion Electroacupuncture can improve the learning and memory of APP/PS1 double-transgenic mice, the age of 6-7 months old is possibly the optimal intervention time of electroacupuncture for AD, but there still requires further mechanism studies.