中文摘要：

目的比较研究近视诱导及正常C57BL6小鼠体重的昼夜波动特点。方法采用离焦镜片进行未成年小鼠的近视诱导,连续2 d以上每隔2 h测量小鼠体重,与同龄对照小鼠的体重昼夜波动进行比较。结果同龄的近视诱导组小鼠体重低于正常对照组（P〈0.05）。两组小鼠体重的昼夜波动达（1.3-1.6）g,其中正常小鼠体重波动呈＂正弦曲线＂样变化,缺乏相对稳定点,而近视诱导组小鼠体重在下午相对稳定。结论 C57BL6小鼠体重的昼夜波动不容忽视。近视诱导可能影响C57BL6小鼠体重的昼夜波动趋势,建议在下午评估实验组小鼠的体重,而正常小鼠的体重测量应固定时间点。

英文摘要：

Objective To compare the characteristics of diurnal fluctuations in body weight of myopia-induced and normal C57BL6 mice. Methods The total body weight was measured during two consecutive days per 2 hours, and the features of weight changes were plotted and compared. Results With the same age, the weight of experiment group was lower than that of the control group （P 〈 0.05）. Diurnal fluctuations of body weight in both groups reached an average of 1.3-1.6 g, and appeared as a ＂sine curve＂ type without stable point in normal cases, however, the weight of myopia-induced mice was relatively stable in the afternoon. Conclusions The diurnal fluctuations in body weight of mice should attract attention. Myopia induction in C57BL6 mice may affect its characteristics. We would recommend evaluating the body weight of experimental mice in the afternoon, while normal mice weight measurements should be at a fixed time point.