中文摘要：

阿尔茨海默病（AD）是目前最为常见的一种神经退行性疾病,其病因及发病机制至今还不是很清楚。近几年,越来越多的研究发现,神经炎症在AD的发生发展过程中发挥着重要作用。其中,小胶质细胞的激活及其产生的炎症因子是AD神经炎症的主要表现。此外,在AD疾病过程中,外周侵入脑内的淋巴细胞及炎症因子也参与了AD的神经炎症。因此,研发副作用小的非甾体类抗炎药有望成为防治AD的新靶点。

英文摘要：

Alzheimer＇s disease（AD） is the most common neurodegenerative disease, and its etiology and pathogenesis are still not very clear so far. In recent years, a growing number of studies have found that neuroinflammation plays an impor- tant role in the development of AD. The activation of microglia and the inflammatory eytokines produced by the cells repre- sent the neuroinflammation in many ways. In addition, peripheral lymphocytes and inflammatory cytokines invading into the brain in AD progress join the neuroinflammation as well. Therefore,the investigation of non-steroidal anti-inflammatory drugs with small side effect may become a new target for prevention and treatment of AD.