中文摘要：

目的探索5-羟色胺2A（5-HT2A）受体基因启动子区-1438G／A多态性与情感性障碍易感性的关系。方法采用限制性片断长度多态性（RFLP）分析技术，检测情感性障碍和正常对照组的5-HT2A受体基因-1438G／A多态性的基因型和等位基因频率，并根据Hardy—Weinberg遗传平衡法则，比较相互之间的区别。结果1．抑郁症5-HT2A受体基因-1438G／A多态性基因型A1／A1频率（58．51％）较正常对照组（42．86％）高，差异有显著性（x^2=3．929，P〈0．05）；2．伴有自杀企图或行为的情感性障碍患者5-HT2A受体基因-1438G／A多态性基因型A1／A2的频率（25．45％）较正常对照组（38．46％）偏低，差异有显著性（x^2=4．74，P〈0．05）。结论5-HT2A受体基因-1438G／A多态性与抑郁症特别是具有自杀企图或行为的患者关联，提示该受体基因多态性可能是抑郁症的易感因子。

英文摘要：

Objective To explore the association between 5-HT2A receptor gene promoter -1438G/A polymorphism and affective disorders. Methods Genotype and allele frequencies -1438G/A polymorphism of 5-HT2A receptor gene in affective disorder and normal controls were examined by PCR-RFLP technique and their difference was compared according to Hardy-Weinberg genetics balance rule. Results The genotype A1/A1 frequence of 5- HT2A receptor gene -1438G/A polymorphism in depression is higher than that in normal controls（ x^2 = 3. 929, P〈 0.05） and affective disorder patients with suicide attempt or behavior have a lower 5-HT2A receptor gene - 1438G/A A1/A2 genotypes frequency compare with normal control＇ s （ x^2 = 4.74, P 〈 0.05 ）. Conclusion 5- HT2A receptor gene -1438G/A polymorphism has an association with depressive patients, especially patients with suicide attempt or behavior, which suggest it may be responsible for a increase in susceptibility for depression.