中文摘要：

目的：介绍近几年来骨形态发生蛋白载体的研究及应用进展。 资料来源：应用计算机检索PubMed 1965-01/2006-07相关骨形态发生蛋白的文章,检索词“Bone Morphogenetic Protein,BMP and carriers”,限定文章语言种类为English。 资料选择：对资料进行初审,选取包括骨形态发生蛋白的文献,然后删除明显与载体无关的研究,对剩余文献查找全文。纳入标准：与骨形态发生蛋白载体研究应用相关的动物实验。排除标准：重复研究、Meta分析类文章。 资料提炼：共检索到1000篇关于骨形态发生蛋白的文献,最终纳入37篇符合标准的文献,分别介绍了骨形态发生蛋白成员载体的研究、临床应用及动物实验。 资料综合：骨形态发生蛋白具有诱导骨形成活性特点,是目前的研究热点。骨形态发生蛋白应用于修复骨缺损需复合适宜的载体,目前已有多种材料用于其载体,有植入性和注射性载体两类,包括生物陶瓷、骨水泥、高分子多聚体、胶原、纤维蛋白凝块等。这些材料理化性质和生物学性质各不相同,因此与骨形态发生蛋白复合后的载体也各具特色。本文介绍了不同载体与骨形态发生蛋白复合体的各自特点,并回顾了各种载体材料的研究和应用现状。 结论：骨形态发生蛋白属于超级转化因子β家族,可诱导骨形成,复合各种载体可应用于骨缺损的修复。

英文摘要：

OBJECTIVE： To introduce the progress in the research and application of the carders for bone morphogenetic protein （BMP）. DATA SOURCES： A computer-based online research of PubMed was undertaken to identify the articles about BMP published in English between January 1965 and July 2006 with the key words of ＂Bone Morphogenetic Protein, BMP and carders＂. STUDY SELECTION： The data were selected pnmarily to choose literature about BMP, and those obviously unrelated to carriers were excluded. The full-text of the rest were searched. Inclusive criteria： clinical application and animal experiment of the carriers for BMP. Exclusive criteria： repetitive studies or Meta analysis. DATA EXTRACTION： Totally 1 000 articles related to BMP were collected and 37 met the inclusive criteria, which introduced the clinical studies or application and animal experiment of member carriers for BMP. DATA SYNTHESIS： BMP has the property of inducing bone formation or osteoinduction; it has become a focus these days. BMP could be used to repair bone defect with suitable carriers. There are various materials as BMP carriers including implantable and injectable carders such as bioceramic, bone cement, macromolecule polymer, collagen, and fibrin sealant. As they have different physiochemicat and biological properties, the composite combined with BMP displays different characters. In this article, we introduced the features of different carrier BMP composites, and reviewed the current state of study and application of the materials as BMP carriers. CONCLUSION： BMP as a member of the transforming growth factor-β superfamily could induce bone formation. BMP combined with suitable carriers may be used to repair bone defects.