中文摘要：

采用电纺丝法成功制备了聚羟基丁酸酯（PHB）电纺丝膜。采用SEM、XRD、力学拉伸等研究方法对其微观形态、力学性能及体外降解行为进行了研究，并讨论了小鼠成纤维细胞（L929）在支架表面的形态，为其在骨组织工程支架上的应用提供理论和实验基础。结果表明纺丝液浓度、注射泵流速以及接收距离等操作参数对PHB纤维的形态有很大的影响。与PHB浇铸膜相比，PHB支架的结晶度及体外降解速率明显大于前者，但拉伸强度和断裂伸长率较小。在支架表面，细胞的形态良好，表明支架具有良好的生物相容性。这种降解性能及生物相容性兼备的PHB骨组织工程支架材料具有潜在的应用前景。

英文摘要：

In this study, poly （3-hydroxybutyrate-co-4-hydroxybutyrate） （PHB） electrospun film was fabricated by electrospinning. The morphology, mechanical properties, degradability and biocompatibility of the scaffold were investigated by SEM, XRD and tensile test etc. The morphology of mouse fibroblast cells （L929） cultured on PHB electrospun film was also studied, whioh provided the application of the bone tissue engineering with theoretical and experimental basis. Final results indicated that morphology of fibers can be influenced by varying the spinning parameters such as concentration of solution, solution flow rate, and distance of the electric field. Compared with cast film the crystallinity and the degradation rate of scaffolds increase remarkably but their tensile strength and the extension rate decrease. The morphology of the cells showed good biocompatibility of the scaffold. These properties make this scaffold a potential candidate as an electrospinning scaffold material for tissue engineering.