中文摘要：

基于生物质资源的平台化学品制造,是解决目前石化资源枯竭和环境问题的重要措施,对经济社会的可持续发展具有重要意义。本文主要介绍了系统生物学和合成生物学在有机酸（琥珀酸、富马酸、L-苹果酸、葡萄糖二酸、丙酮酸、苯丙酮酸、α-酮戊二酸）以及其他平台化学品（2,5-呋喃二甲酸）生物制造中的应用,并展望了生物制造在平台化学品生产中的未来发展方向。

英文摘要：

Due to the limited amount of fossil fuels and global warming problem, bio-manufacturing based on renewable biomass has been paid more attention. In this review, the contribution of systems biology and synthetic biology in bio-manufacture of platform chemicals like organic acid such as succinate, fumarate, malate, glucaric acid, pyruvate, phenylpyruvic acid, α-ketoglutarate and other platform chemicals such as 2,5-furandicarboxylic acid are reviewed. Finally, the trends of bio-manufacture for platform chemical are prospected.