中文摘要：

目的 研究血管诱导生成因子61（CYR61）和血管内皮生长因子（VEGF）在结外鼻型NK／T细胞淋巴瘤中的表达及其意义。方法 应用实时荧光定量PCR和免疫组化技术分别检测结外鼻型NK／T细胞淋巴瘤中CYR61 mRNA、VEGF mRNA及其蛋白水平表达。结果 ①经实时荧光定量PCR检测，20例中有19例（95．0％）CYR61 mRNA表达上调，15例（75．0％）VEGF mRNA表达上调。②经免疫组织化学染色，40例中有38例（95．0％）肿瘤细胞CYR61蛋白阳性，25例（62．5％）VEGF蛋白阳性，与对照组比较差异均无统计学意义；CYR61和VEGF在mRNA和蛋白水平表达的一致率分别为95．0％和65．0％；8例患者CYR61 mRNA、VEGF mRNA及其蛋白表达一致。③通过生存分析显示CYR61 mRNA和VEGF mRNA表达上调者预后较差，CYR61和VEGF表达水平与结外鼻型NK／T细胞淋巴瘤的预后相关。结论 CYR61和VEGF在结外鼻型NK／T细胞淋巴瘤中的表达水平有变化，并与该肿瘤的预后可能有一定的关系。

英文摘要：

Objective To investigate the expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and its significance. Methods CYR61 mRNA and VEGF mRNA were detected by realtime fluorescence quantitative PCR method in 20 cases of extranodal nasal-type NK/T cell lymphoma. Expressions of CYR61 and VEGF were studied by immunohistochemistry in 40 cases of the tumor. Results ①Overexpression of CYR61 mRNA and VEGF mRNA was found in 19/20（95.0% ） and 15/20（75.0% ） cases, respectively. ②Tumor cells expressing CYR61 protein and VEGF protein were detected in 38 （95.0%） and 25 （62.5%） of the 40 cases respectively, being no significant difference from the control. Co-expression of CYR61 and VEGF at both the mRNA and protein levels was 95.0% and 65.0% , respectively. Over-expression of CYR61 and VEGF at both mRNA and protein levels was found in 8 of the 40 cases. ③ The prognosis of the patients over-expressing CYR61 and VEGF was worse. Conclusion In extranodal nasal-type NK/T cell lymphoma, the expression level of CYR61 and VEGF was changed and it may be of prognostic implication of the tumor.