中文摘要：

乌头属植物是珍贵的药并且另外有毒的材料，它能仅仅在 detoxification 处理以后被使用。尽管传统的处理方法能完成需要的 detoxification 效果，有一些明显的缺点，包括碱和差的优秀一致性的重要损失。开发一条新 detoxification 途径因此是必要的。在现在的学习，我们由快速弄干新鲜切割的乌头属植物粒子设计了一条新奇一步舞 detoxification 途径。以便评估技术优点， mesaconitine 的内容，附子精， hypaconitine， benzoylmesaconine， benzoylaconine， benzoylhypaconine， neoline， fuziline， songorine，和 talatisamine 用 HPLC 和 UHPLC/Q-TOF-MS 是坚定的。Multivariate 分析方法例如聚类分析和原则部件分析，被使用决定样品之间的优秀差别。我们的结果证明传统的过程能减少需要的毒性，而且导致了超过 85.2% 碱损失。然而，我们的新奇一步舞方法能够几乎完成一样的 detoxification 效果，与仅仅约 30% 碱损失。簇分析和主要部件分析分析建议了那 Shengfupian，新奇产品与各种各样的传统的产品显著地不同。测试的尖锐毒性证明新奇产品完成了好 detoxification 效果，与它等价于 20 次成年剂量的最大的容忍的剂量。并且测试的心脏的效果也证明新奇产品的活动比传统的产品的强壮。而且，粒子说明极大地改进了新奇产品的优秀一致性，它比传统的产品极其优异。这些结果将帮助指导处理技术的乌头属植物的合理优化，提供为临床的处理的更好的药。

英文摘要：

Aconite is a valuable drug and also a toxic material, which can be used only after detoxification processing. Although traditional processing methods can achieve detoxification effect as desired, there are some obvious drawbacks, including a significant loss of alkaloids and poor quality consistency. It is thus necessary to develop a new detoxification approach. In the present study, we designed a novel one-step detoxification approach by quickly drying fresh-cut aconite particles. In order to evaluate the technical advantages, the contents of mesaconitine, aconitine, hypaconitine, benzoylmesaconine, benzoylaconine, benzoylhypaconine, neoline, fuziline, songorine, and talatisamine were determined using HPLC and UHPLC/Q-TOF-MS. Multivariate analysis methods, such as Clustering analysis and Principle component analysis, were applied to determine the quality differences between samples. Our results showed that traditional processes could reduce toxicity as desired, but also led to more than 85.2% alkaloids loss. However, our novel one-step method was capable of achieving virtually the same detoxification effect, with only an approximately 30% alkaloids loss. Cluster analysis and Principal component analysis analyses suggested that Shengfupian and the novel products were significantly different from various traditional products. Acute toxicity testing showed that the novel products achieved a good detoxification effect, with its maximum tolerated dose being equivalent to 20 times of adult dosage. And cardiac effect testing also showed that the activity of the novel products was stronger than that of traditional products. Moreover, particles specification greatly improved the quality consistency of the novel products, which was immensely superior to the traditional products. These results would help guide the rational optimization of aconite processing technologies, providing better drugs for clinical treatment.