中文摘要：

3D打印复合成形工艺将3D打印技术与静电纺丝技术相结合，在构建具有多尺度多梯度结构特征的，生物硬组织修复用再生支架方面表现出独特优势。提出一种针对3D打印复合成形工艺的生物CAD／CAM系统构建方法，不仅能实现成形过程的自动监控，保证多工艺的柔性复合，而且能实现从STL模型，到生成加工路径信息，并最终驱动系统硬件进行加工的自动化处理流程。该系统及方法将生物建模软件与生物3D打印复合成形系统有效集成，将CAD过程中无法建模的尺度信息与来自CAD的加工信息有机结合并处理，有效解决了3D打印成形再生支架时，精度受限而无法在支架内部成形微观尺度结构的问题。最后，通过骨组织工程支架的制备试验验证了系统的有效性。

英文摘要：

The 3D printing composite forming process combines 3D printing technology with electro spinning technology. The composite forming process has obviously advantages in forming regenerative scaffolds with multi-scale and gradient structure which are most important for repairing some damaged tissue. Present a biological CAD/CAM system aiming at the 3D printing composite forming process. This system achieves not only the automatic monitoring of the forming process to ensure flexible composition of multi-process but also the automatic processing flow which is from STL model to the driver files of the processing hardware. Since the proposed system and method integrates the biological modeling software and the biological 3D printing composite forming system, the multi-scale information that can be included into CAD model or not can both be effectively processed, which is just the most obvious advantage of the proposed system and method. Ultimately, the effectiveness of the proposed system is verified by forming some bone tissue scaffolds.