中文摘要：

设计一种新型血管支架用于血管狭窄治疗．针对目前制备生物可吸收血管支架（BVS）在装备和技术上的不足，提出了结合生物3D打印和静电纺丝制备复合生物可吸收血管支架（CBVS）的新方法．首先，用PPDO材料通过3D打印制备支架内层；然后，配制壳聚糖和PVA混合溶液，通过静电纺丝制备支架外层．力学性能测试显示，结合3D打印和静电纺丝制备的支架要好于仅采用3D打印制备的支架．在支架上种植细胞试验表明，细胞在支架上有良好的粘附和增殖，因为外层含有天然生物材料壳聚糖．所提出的复合成形工艺和方法，为后续构建可控携载药物支架提供了很好的思路．该CBVS可用于血管狭窄治疗．

英文摘要：

A new type of vascular stent is designed for treating stenotic vessels. Aiming at overcoming the shortcomings of existing equipment and technology for preparing a bioabsorbable vascular stent （BVS）, a new method which combines 3D bio-printing and electrospinning to prepare the composite bioabsorbable vascular stent （CBVS） is proposed. The inner layer of the CBVS can be obtained through 3D bio- printing using poly-p-dioxanone （PPDO）. The thin nanofiber film that serves as the outer layer can be built through electrospinning using mixtures of chitosan-PVA （poly （vinyl alcohol））. Tests of mechanical properties show that the stent prepared through 3D bio-printing combined with electrospinning is better than that prepared through 3D bio- printing alone. Cells cultivated on the CBVS adhere and proliferate better due to the natural, biological chitosan in the outer layer. The proposed complex process and method can provide a good basis for preparing a controllable drug-carrying vascular stent. Overall, the CBVS can be a good candidate for treating stenotic vessels.