姜黄(Curcuma longa L.)为姜科姜黄属植物,药用其根茎,主产于中国、印度、日本等国家.1870年从姜黄属植物中分离出姜黄素,1910年Lampe等首先阐明了其化学结构.现已证明其具有抗肿瘤、抑炎、利胆、抗氧化、抗肝细胞毒性、抗风湿、抑菌、抗低血压、低胆固醇等广泛的药理作用.目前对其化学结构进行修饰已成为国内外研究的热点.本文就目前对姜黄素衍生物的研究进展做一综述.
Curcuma longa L. is a plant of Zingiberaceae and Curcuma genus, which grow India and Japan, and its root is used as medicine. In 1870 curcumin was separated mainly in such countries as China, from the plants of Curcuma genus and in 1910 Lampe and other scholars first expounded its chemical construction.It is proved that curcumin has extensive pharmacological functions, such as anti -tumor, anti -inflamination, anti -oxidation, anti -hapatoxin, anti -rheumatism, bacteriostasis, anti-hypotension and the reduction of cholesteral. At present studies are focused on the modification of its chemical construction at home and abroad. This article summarizes the progress of the present studies in curcumin derivatives.