中文摘要：

尼达尼布是用于特发性肺纤维化治疗的小分子化学药物,作为一种可抑制血管生成和组织纤维化的多靶点受体酪氨酸激酶抑制剂,近年大量研究表明尼达尼布具有较好的抗肿瘤作用,其与抗肿瘤药物联用可提高抗肿瘤疗效。文章通过查阅文献及临床研究报告,对尼达尼布的临床前抑瘤作用及在多种肿瘤治疗中的临床试验研究进行了综述,为尼达尼布进一步的抗肿瘤研究开发提供参考。

英文摘要：

Nintedanib is a small chemical drug for the treatment of idiopathic pulmonary fibrosis,and as a kind of multi-target receptor tyrosine kinase inhibitor which inhibits angiogenesis and tissue fibrosis. A large number of studies in recent years have shown that nintedanib had a good anti-tumor effect,and the effects of some anti-tumor drugs could be enhanced in combination with nintedanib. In this paper,the preclinical antitumor effect of nintedanib and the clinical trial of various tumor treatments were reviewed by consulting literatures and clinical study results,providing a reference for further anti-tumor research and development of nintedanib.