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Fabrication and characterization of novel tentacle-type adsorbent for resolution of chiral drugs
  • ISSN号:1001-6538
  • 期刊名称:Chinese Science Bulletin
  • 时间:2013.9
  • 页码:3390-3397
  • 分类:O647.33[理学—物理化学;理学—化学] TQ463[化学工程—制药化工]
  • 作者机构:[1]Department of Pharmaceutical & Biological Engineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, China
  • 相关基金:supported by the Doctoral Fund of Ministry of Education of China (20090181110043)
  • 相关项目:离子液体应用于天然药物水溶性代表成分分离及水解的方法学和关键问题研究
中文摘要:

基于硅石,胶化与 -cyclodextrin 修改了的新奇触手类型 chiral 吸附物(-CD) 和聚乙烯化合物的酒精(PVA ) 被表面 grafting 综合技术。用产生吸附物的 chiral 药品的吸附行为被调查。在学习,英尺红外和 thermogravimetric 分析(TGA ) 被采用描绘吸附物的化学、物理的性质;mandelic 酸(麻省) 用作模型溶质评估吸着能力和吸附物的选择。试验性的结果证明新奇触手类型吸附物超过常规的具有更大的平衡吸附能力和更好的选择并且能作为潜在的 chiral 是静止阶段(CSP ) 。

英文摘要:

Novel tentacle-type chiral adsorbent based on silica gels modified with β-cyclodextrin (β-CD) and polyvinyl alcohol(PVA) is synthesized by surface grafting technique. The adsorption behavior of chiral pharmaceuticals using the resulting adsorbents is investigated. In the study, FT-IR and thermogravimetric analysis (TGA) are employed to characterize the chemical and physical properties of the adsorbent; mandelic acid (MA) serves as model solute to evaluate the sorption capacity and selectivity of the adsorbent. The experimental results show that the novel tentacle-type adsorbent is possessed of larger equilibrium adsorption capacity and better selectivity over the conventional one and could be as potential chiral stationary phase (CSPs).

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