中文摘要：

目的从显微形态及超微结构层面探讨天麻舒心方对自发性高血压大鼠（SHR）阻力血管富营养重塑的干预效果。方法中药高、中、低剂量组,阳性对照组（对照组）,模型对照组（模型组）,各10只SHR;10只Wistar大鼠作为正常对照组（空白组）,各给药组分别给予相应剂量的天麻舒心浸膏液、氯沙坦钾混悬液,模型组及空白组予以相同体积的蒸馏水。18周后,处死动物并留取肠系膜三级动脉标本;倒置相差显微镜观察血管显微形态,测定并计算管腔外直径、管腔内直径、中膜厚度、中膜横断面面积、中膜厚度/管腔内半径;透射电子显微镜观察肠系膜三级动脉超微结构。结果与空白组比较,模型组中膜横断面面积未见改变,差异无统计学意义（P〉0.05）;管腔外直径、管腔内直径减少,差异有统计学意义（P〈0.05,P〈0.01）;中膜厚度、中膜厚度/内腔半径增加,差异有统计学意义（P〈0.01）,内弹力层不连续,中膜SMC变形、胶原纤维增生。与模型组比较,对照组和中药各剂量组管腔内直径均增加,差异有统计学意义（P〈0.05,P〈0.01）;中膜厚度、中膜厚度/内半径均减少,差异亦有统计学意义（P〈0.05,P〈0.01）,内弹力层、中膜平滑肌细胞变形及胶原纤维增生得到不同程度改善。结论 SHR阻力血管出现富营养重塑,天麻舒心方可以从显微形态及超微结构等层面改善高血压阻力血管富营养重塑。

英文摘要：

Objective To investigate the effects of Tianma Shuxin Recipe on the eutrophic remodeling of resistance vessel in spontaneously hypertensive rats （SHR） from the microstructure and uhrastructure. Methods SHR were randomly divided into the high- dose, medium-dose and low-dose of Tianma Shuxin Recipe treated group, positive control group （ control group） and model control group （model group） of 10 each. 10 Wistar rats were designed as blank control group （blank group） . The medicated groups were treated with the high, medium and low dose of Tianma Shuxin extract, losartan potassium suspension and the model group and blank group were given distilled water of the same volume respectively. After 18 weeks, animals were sacrificed and the specimens of the third-grade branch of mesentery artery were made. The vascular microstructures such as vascular external diameter, vascular internal diameter, thickness of tunica media, cross section area of tunica media, thickness of tunica media/vascular internal radius were evaluated by inverted phase contrast microscope. The vascular ultrastrnctures were observed by transmission electron microscopy. Results Compared with the blank group, the model group showed the unchanged cross section area of tunica media （P 〉 0. 05）, the difference was not statistically significant （ P 〉 0. 05 ） ; the decreased vascular external diameter and vascular internal diameter, the differences were statistically significant （P 〈 0. 05, P 〈 0. 01 ）, the increased thickness of tunica media and thickness of tunica media/ vascular internal radius, the differences were statistically significant （ P 〈 0. 01 ）, discontinuous internal elastic lamina, deformed media smooth muscle cells and collagen proliferation. Compared with the model group, the control group and Tianma Shuxin Recipe treated groups showed increased vascular internal diameter, the differences were statistically significant（P 〈 0.05, P 〈 0. 01 ）, the decreased thickness of tunica media and thickne