中文摘要：

目的探讨18β-甘草次酸对2型糖尿病大鼠血糖、血脂及胰岛素敏感性的影响。方法采用高脂高糖饲料诱导结合-次性小剂量注射链脲佐菌素的方法建立2型糖尿病大鼠模型。将大鼠随机分为正常对照组（CON）、正常给药组（CGA）、糖尿病组（DM）、糖尿病＋甘草次酸治疗组（DGA）、糖尿病＋格列苯脲阳性对照组（DGL），采用灌胃方式分别给予溶剂（5％DMSO）、18β-甘草次酸[100mg／（kg·d）]和格列苯脲[600μg／（kg·d）]。45d后，检测实验大鼠的空腹血糖（FBG）、血脂（TG、TC、LDL-C和HDL—C）以及血清胰岛素。结果18B-甘草次酸显著降低了糖尿病大鼠的FBG、TG、TC、LDL—C和胰岛素抵抗指数（HOMA—IR），并升高了其抗动脉粥样硬化指数（AAI）。结论18β-甘草次酸能有效降低2型糖尿病大鼠的血糖和血脂，改善胰岛素抵抗。

英文摘要：

[ Objective ] To explore the effect of 18β-glycyrrhetinic acid on fasting blood glucose （FBG）, lipids and sensitivity of insulin in type 2 diabetic rats. [Methods ] Type 2 diabetes model was replicated by high-fat- high-sugar diet combined with lower dose STZ injection. All rats were randomly divided into five groups： control group（CON）, control 18β-glycyrrhetinic acid treatment group （CGA）, diabetes group （DM）, DM＋18β-glycyrrhetinic acid treatment group （DGA） and DM＋glibenclamide treatment group （DGL）. They were orally administered with 5% DMSO, 18β-glycyrrhetinie acid[100mg/（kg. d）] and glibenclamide [600μg/（kg. d）] respectively. After 45 days of con- tinuous medication, detect fasting blood glueose（FBG）, lipids（TG, TC, LDL-C, HDL-C） and insulin level in serum of all rats. [Results] 18β-glycyrrhetinic acid treatment significantly decreased the levels of FBG, TG, TC, LDL-C and homeostasis model assessment of insulin resistance （HOMA-IR） in diabetic rats, and also increased anti- atheroselerosis index（AAI）. [ Conclusion] 18β-glycyrrhetinic acid has hypoglycemic and hypolipidemic effects,and it can also ameliorate insulin resistance.