中文摘要：

中颢视区（middle temporal area、MT／V5）在视觉运动处理过程中起着重要作用。MT区神经元对物体运动方向具有强选择性，而这种细胞的方向选择性被认为是运动方向知觉的神经基础，且已有实验表明方向选择性由于受到注意影响，而在时间进程上分为2个阶段。该研究组先前的实验发现麻醉猕猴（Rhesus macaque）MT区细胞的方向选择性发生了衰退，但该衰退是整个时间进程上平均的结果，并不能在时间进程上揭示其神经机制。因此，为了进一步探索运动方向感知能力下降的神经机制，该实验采用单细胞技术在麻醉猕猴的MT区研究了在正常老化过程中MT区细胞的早期方向选择性变化（early stage direction selectivity, esDB），结果表明老年猕猴MT区细胞早期方向选择性显著降低，具有强早期方向选择性的细胞显著减少。该结果进一步揭示了MT区细胞方向选择性在早期发生的衰退可能介导了视觉运动感知能力的下降。

英文摘要：

The middle temporal area （MT/V5） plays an important role in motion processing. Neurons in this area have a strongly selective response to the moving direction of objects and as such, the selectivity of MT neurons was proposed to be a neural mechanism for the perception of motion. Our previous studies have found degradation in direction selectivity of MT neurons in old monkeys, but this direction selectivity was calculated during the whole response time and the results were not able to uncover the mechanism of motion perception over a time course. Furthermore, experiments have found that direction selectivity was enhanced by attention at a later stage. Therefore, the response should be excluded in experiments with anesthesia. To further characterize the neural mechanism over a time course, we investigated the age-related changes of direction selectivity in the early stage by comparing the proportions of direction selective MT cells in old and young macaque monkeys using in vivo single-cell recording techniques. Our results show that the proportion of early-stage-direction-selective cells is lower in old monkeys than in young monkeys, and that the early stage direction bias （esDB） of old MT cells decreased relative to young MT cells. Furthermore, the proportion of MT cells having strong early stage direction selectivity in old monkeys was decreased. Accordingly, the functional degradation in the early stage of MT cells may mediate perceptual declines of old primates in visual motion tasks.