中文摘要：

两性霉素B自上市以来，一直是临床上治疗深部真菌感染的首选药物，主要通过选择性地破坏真菌细胞膜来发挥疗效。但是由于其水溶性差、口服生物利用度低以及毒副作用强等缺陷，临床应用受到很大的限制。多年来许多科研工作者不断致力于其作用机制以及结构改造的研究，取得了显著的成果。本文对两性霉素B结构改造的进展做一简要综述，以期对其相关研究提供有价值的参考。

英文摘要：

Amphotericin B has been the first choice of clinical drugs to treat systemic mycosis since it was launchedon the market, which makes full use of its curative effects by selectively disrupting the cell membrane of fungi. But its clin-ical applications are greatly limited due to several drawbacks, such as poor solubility low bioavailability, severe sideeffects, etc. Many scientists have devoted themselves to explore the mechanism of action and structural modification of am-photericin B over the years, and achieved significant results.This article briefly reviewed the progress in structural modifi-cation of amphotericin B, aiming at providing valuable information for related research.