基于底物设计的概念,建立了一种以β-羰基二硫代羧酸酯和取代邻溴代苯乙酮为合成子,在碘化亚铜/邻菲罗啉促进下高化学选择性地合成硫代色酮类衍生物的新方法.该方法高效、简便且收率高.
A new methodology to high chemoselectively synthesize thiochromone derivatives from β-oxodithioesters and substituted o-bromoacetophenones promoted by CuI/1,10-phen system based on the substrate-design concept has been developed. This approach has advantages of simple and efficient operation, and high yields.