中文摘要：

目的调查17个Y染色体短串联重复序列（Y-STR）基因座及其单倍型在新疆昌吉地区维吾尔族人群中的分布情况。方法采用AmpFlSTR YfilerTM荧光标记复合扩增系统,对154名维吾尔族无关男性个体血样进行17个Y-STR位点的复合扩增,用ABI 3130XL遗传分析仪对扩增产物进行检测分析。结果DYS456、DYS389Ⅰ、DYS390、DYS389Ⅱ、DYS458、DYS19、DYS385a/b、DYS393、DYS391、DYS439、DYS635、DYS392、Y-GATA-H4、DYS437、DYS438、DYS448各位点遗传多样性（GD值）分布在0.529 7～0.959 9之间;17个Y-STR位点共观察到单倍型151种,其单倍型多样性GD值为0.999 7。结论新疆昌吉地区维吾尔族17个Y-STR位点具有丰富的遗传多样性,可为父权鉴定和父系进化研究提供有价值的遗传学资料。

英文摘要：

Objective To investigate the allelic and haplotype frequency distribution of seventeen short tandem repeat loci of Y chromosome in Xinjiang Uygur population in Changji.Methods Seventeen Y-STR loci of which the template DNAs were extracted from blood samples of 154 unrelated male individuals in Uygur population,were amplified by using the AmpFlSTR YfilerTM.The PCR products were analyzed and genotyped with ABI3130XL Sequencer.Results The gene diversity ranged from 0.529 7 to 0.959 9 at DYS456,DYS389Ⅰ,DYS390,DYS389Ⅱ,DYS458,DYS19,DYS385a/b,DYS393,DYS391,DYS439,DYS635,DYS392,Y-GATA-H4,DYS437,DYS438,and DYS448.A total of 151 different haplotypes were observed.The haplotype diversity value calculated from all 17 loci was 0.999 7.Conclusion The 17th Y-STR loci in Xinjiang Uygur population in Changji are highly affluent genetic polymorphic and can offer valuable genetic datas for paternity testing and paternal genetic lineages evolution.