中文摘要：

MicroRNAs (miRNAs ) 是 ~ 的短非编码的 RNA 在特定的肿瘤微型环境包括肿瘤改编，幸存，和新陈代谢动态平衡在多样的生物功能起重要作用的 22 核苷酸，例如组织缺氧和低 pH。组织缺氧在肿瘤开发和前进期间是一个唯一的生理的条件，它改变一套调停组织缺氧的 miRNAs 表示。这些调停组织缺氧的 miRNAs 可以展出 oncogenic 活动或肿瘤镇压的活动，主要通过包括组织缺氧可诱导的因素发信号的细胞的小径的规定。酸的肿瘤微型环境由于不完全的 vascularization 由于占优势的 glycolytic 新陈代谢(Warburg 效果) 和差的液体清理的联合在 hypoxic 固体肿瘤发展。在这评论，我们在组织缺氧和酸的肿瘤微型环境总结我们 miRNAs 的新兴的角色的当前的理解。

英文摘要：

MicroRNAs （miRNAs） are short non-coding RNAs of ,-22 nucleotides that play important roles in diverse biological functions including tumor adaption, survival, and metabolism homeostasis in specific tumor microenvironment, such as hypoxia and low pH. Hypoxia is a unique physiological condition during tumor development and progression, which alters a set of hypoxia-mediated miRNAs expression. These hypoxia-mediated miRNAs may exhibit either oncogenic activities or tumor-suppres sive activities, mainly through the regulation of cellular pathways including hypoxia-inducible factors signaling. Acidic tumor microenvironment develops in hypoxic solid tumors due to a combination of predominant glycolytic metabolism （Warburg effect） and poor fluid clearance due to incomplete vascularization. In this review, we summarize our current understanding of the emerging roles of miRNAs in hypoxia and acidic tumor microenvironment.