中文摘要：

目的探讨非酒精性单纯性脂肪肝（NAFL）与估计肾小球滤过率（e GFR）水平的相关性。方法收集2014年1-6月浙江大学医学院附属第一医院门诊健康体检人群881例,检测谷氨酰转肽酶（GGT）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、空腹血糖（FPG）、尿酸（UA）、血清肌酐和肝脏超声,同时测量身高、体重、腰围（WC）、收缩压（SBP）、舒张压（DBP）,计算体重指数（BMI）及e GFR。结果 881例体检人群中,NAFL 274例〔男212例,女62例,平均年龄（48.0±7.3）岁〕,健康人群607例〔男321例,女286例,平均年龄（47.7±8.8）岁〕,两组性别、SBP、DBP、UA、GGT、TG、TC、HDL-C、LDL-C、FPG、WC、BMI、e GFR水平具有统计学差异（所有P〈0.05）,NAFL人群e GFR平均水平低于健康人群〔（107.5±20.0）ml·min^-1·1.73 m^-2vs.（112.8±24.6）ml·min^-1·1.73 m^-2〕。按e GFR水平从低到高将研究人群平均分成四组,发现NAFL患病率呈相应的下降趋势（P趋势值=0.019）。经年龄、性别校正后,Spearman相关性分析显示e GFR与DBP、WC、BMI、GGT、TG、TC、LDL-C、UA等NAFL相关危险因素呈负相关性（所有P〈0.05）。结论 e GFR与NAFL及其相关危险因素密切相关,NAFL可对e GFR产生影响,非酒精性脂肪性肝病（NAFLD）可能是导致e GFR水平下降的危险因素之一。

英文摘要：

Objective To analyze the relationship between nonalcoholic simple fatty liver（ NAFL） and estimated glomerular filtration rate（ e GFR）,further to investigate the effects of NAFLD on renal function. Methods 881 cases from January to June in 2014 in the First Affiliated Hospital,College of Medicine,Zhejiang University,were collected to detect glutamyl transpeptidase（ GGT）,triglyceride（ TG）,total cholesterol（ TC）,high density lipoprotein cholesterol（ HDL-C）,low density lipoprotein cholesterol（ LDL-C）,fasting blood glucose（ FPG）,uric acid（ UA） and hepatic ultrasound,measure the height,weight,waist circumference（ WC）,systolic blood pressure（ SBP） and diastolic blood pressure（ DBP）,and count body mass index（ BMI） and e GFR. Results In the 881 cases,there were 274 cases of NAFL〔（ 212 males,62 females,mean age for（ 48. 0 ± 7. 3） years〕. There were 607 healthy persons〔321 males,286 females,mean age for（ 47. 7 ± 8. 8）years〕. There were significant differences between the two groups in terms of gender,SBP,DBP,UA,GGT,TG,TC,HDL-C,LDL-C,FPG,WC,BMI and e GFR levels（ all P〈0. 05）. The mean e GFR level of NAFL was lower than that of healthy population〔（ 107. 5 ± 20. 0） vs（ 112. 8 ± 24. 6） ml·min^-1·1. 73 m^-2〕. The subjects were divided into four groups based on e GFR level from low to high,the prevalence of NAFL was a corresponding decline（ Ptrend = 0. 019）. After age and gender correction,Spearman correlation analysis showed that e GFR was negatively correlated with NAFLD-related risk factors such as DBP,WC,BMI,GGT,TG,TC,LDL-C and UA（ all P〈0. 05）. Conclusions e GFR is closely related with NAFL and its related factors and NAFL can influence e GFR,NAFLD is one of risk factors resulting in the decline of e GFR.