中文摘要：

目的探讨表皮生长因子（EGF）G61A位点（EGF＋61）多态性与慢性乙型肝炎肝细胞癌的相关性。方法运用多聚酶链式反应-限制性片段长度多态性（PCR-RFLP）技术，检测中国人群中215例慢性乙型肝炎肝细胞癌患者和104例正常对照者EGF＋61位点的基因型，分析基因型及等位基因的分布频率。结果EGF＋61位点基因型及等位基因在乙型肝炎肝细胞癌患者及对照者的分布频率差异均无统计学意义。TNMⅠ、Ⅱ及TNMⅢ、Ⅳ两组的基因型及等位基因的分布频率差异也无统计学意义。结论在中国人群中，EGF＋61位点的基因多态性与乙型肝炎肝细胞癌的发生和进展程度无密切关系。

英文摘要：

Objective To explore the relationship between polymorphism of gene at G61A site of epidermal growth factor （EGF＋61） and hepatocellular carcinoma （HCC） in the patients with chronic hepatitis B virus （HBV） infection in China. Methods A total of 215 HCC patients with chronic HBV infection were analyzed for genotypes of EGF ＋61 genes by PCR-RFLP, and evaluated for the distribution frequency of allele, using 104 healthy persons as control. Results No significant difference were observed in the genotypes of EGF ＋61 genes and distribution frequencies of alleles between HCC patients and healthy persons or between the HCC patients at TNM stages Ⅰ, Ⅱ and Ⅲ, Ⅳ. Conclusion The polymorphism of EGF＋61 gene showed no close relationship to the occurrence and progression of HCC in patients with chronic HBV infection in China.