中文摘要：

目的研究3-乙酰基-11-羰基-β乳香酸（AKBA）在大鼠体内的代谢途径。方法大鼠igAKBA60mg／kg后，收集胆汁、尿液及粪便，应用高效液相色谱-四级杆-离子阱质谱（HPLC—QTRAP—MS）技术分析AKBA在大鼠体内的代谢途径。结果共检测到除原形药物外的15个代谢产物，提示AKBA在大鼠体内的主要代谢途径为去乙酰化、单羟基化、脱氢化及葡萄糖醛酸结合物。结论AKBA在大鼠体内经历了广泛的Ⅰ相、Ⅱ相代谢，产生的代谢产物主要通过粪便及胆汁排泄；利用QTRAP技术的自动切换扫描（IDA）软件及增强型产物离子（EPI）扫描功能，能够快速得到高质量的MS^2谱图，为AKBA代谢产物的鉴定提供了有效的检测手段。

英文摘要：

Objective To study the in vivo metabolic pathways of 3-acetyl-11-keto-β-boswellic acid （AKBA） in rats. Methods An HPLC-QTRAP-MS method was applied to identifying the metabolites of AKBA in bile, urine, and feces after ig administration of AKBA 60 mg/kg to rats. Results A total of 15 metabolites were found in rats. The major metabolic pathways of AKBA were deacetylation, mono-hydroxylation, dehydrogenation, and glucuronide conjugates. Conclusion AKBA undergoes the extensive phases I and II metabolism in rats; The metabolites produced mainly excrete through feces and bile; The information-dependent acquisition （IDA） and enhanced product ion （EPI） scan were used on a linear ion trap mass spectrometer to get high quality MS2 picture and provide an effective method for identifying the metabolites of AKBA.