中文摘要：

目的 探讨重症肌无力（MG）患者嗅觉功能及其与临床特征的相关性.方法 利用T＆amp;T嗅觉检测法对自2014年3-7月在天津医科大学总医院神经内科确诊的61例重症肌无力患者和32名健康对照进行嗅觉检测,收集MG患者临床信息,利用Spearman相关性分析嗅觉功能与临床特征的相关性.结果 重症肌无力患者嗅觉识别阈为（2.07±1.56）,健康对照嗅觉识别阈为（0.31±1.25）,二者差异具有统计学意义（t=5.50,P＜0.01）,Spearman相关分析显示重症肌无力患者嗅觉水平与病程（r =0.348,P=1.006）、疾病严重程度定量（QMG）评分（r=0.393,P=0.025）、每日生存活动等级（ADL）评分（r=0.421,P=0.01）和累计服用溴吡斯的明的时间（r=0.295,P=0.025）呈正相关;与累计服用泼尼松时间（r=0.084,P=0.053）、服用免疫抑制剂时间（r=0.153,P=0.251）无相关性.结论 重症肌无力患者存在嗅觉功能下降,提示重症肌无力患者可能存在不可忽视的非运动功能损害.

英文摘要：

Objective To explore the olfactory function of patients with myasthenia gravis （MG） and analyze the correlation between olfactory dysfunction and clinical characteristics.Methods A total of 61 MG patients from March to July 2014 and 32 healthy controls （HC） received T＆amp;T olfactometer test.Their clinical data were collected.And the relationship of T＆amp;T score and clinical characteristics were analyzed.Results The identification threshold of T＆amp;T olfactometer test was （2.07 ± 1.56） versus （0.31 ±1.25） for healthy controls.MG patients had a worse performance on olfaction test than healthy controls （t =5.50,P 〈 0.01）.By Spearman＇s analysis,disease course （r =1.348,P =0.006）,QMG scores （r =0.393,P =0.025）,ADL scores （r =0.421,P =0.01） and dosing time of pyridostigmine （r =0.295,P=0.025） were positively correlated with T＆T scores.However,the dosing times of prednisone （r =0.084,P =0.053） or immunodepressants （r =0.153,P =0.251） were not correlated with T＆amp;T scores.Conclusion MG patients have poor olfactory sensation.And a potential involvement of non-motor system shall attract the attention of neurologists.