中文摘要：

目的研究视神经脊髓炎（neuromyelitis optica,NMO）患者血清中超敏C-反应蛋白（high sensitivity C-reactive protein,hs-CRP）水平及其与疾病临床特点的相关性。方法测定并比较50例NMO急性期患者、30例重症肌无力（myasthenia gravis,MG）患者（作为疾病对照）、58名健康对照者的血清hs-CRP水平,并分析50例NMO急性期血清hs-CRP水平与其临床特点的相关性;同时比较NMO患者的急性期与缓解期的血清hsCRP水平。结果 NMO急性期组血清hs-CRP水平为（2.2±2.7）mg/L,MG组为（0.8±0.9）mg/L,健康对照组为（0.8±0.9）mg/L,三组间比较差异有统计学意义（F=8.834,P〈0.001）,NMO急性期组高于MG组（t=3.204,P=0.002）及健康对照组（t=3.508,P=0.001）。31例NMO急性期患者经治疗后病情稳定缓解,急性期血清hs-CRP水平〔（2.7±3.2）mg/L〕高于NMO缓解期〔（1.2±1.3）mg/L〕（t=2.797,P=0.009）。50例NMO急性期患者血清hs-CRP水平与复发的间隔时间呈负相关（r=-0.445,P=0.038）,与患者首发年龄、扩展残疾状态量表（EDSS）评分、脊髓MRI受累节段数、水通道蛋白4抗体（AQP4-Ab）水平无相关性（均P〉0.05）。结论 NMO患者血清hs-CRP水平与其疾病活动性密切相关。血清hs-CRP水平可能对下一次复发时间有一定预示作用,但不能反映疾病的严重程度。

英文摘要：

Objective To investigate the relationship of the serum high sensitivity C-reactive protein（hs-CRP）level with the clinical features of acute neuromyelitis optica（NMO）patients.Methods The serum hsCRP levels were measured and analyzed in 50 acute NMO patients,30 myasthenia gravis（MG）patients and 58age-and sex-matched healthy controls（HC）.The correlation between serum hs-CRP levels and clinical features of NMO were analyzed.The serum hs-CRP levels of the acute and remit period of NMO patients were compared.Results The serum hs-CRP levels in acute NMO group,the MG and HC groups were（2.2±2.7）mg/L,（0.8±0.9）mg/L and（0.8±0.9）mg/L.There were significant differences of serum hs-CRP levels among the three group（F=8.834,P〈0.001）.The serum hs-CRP levels in acute NMO patients were significantly higher than those in MG patients（t=3.204,P=0.002）and HC（t=3.508,P=0.001）,while there were no differences between MG group and HC groups（P〉0.05）.The serum hs-CRP levels of 31 remit NMO patients with remission after treatment[（1.2±1.3）mg/L]was lower than that of the acute ones[（2.7±3.2）mg/L,t=2.797,P=0.009].In acute NMO group,serum hs-CRP levels were negatively correlated with the time to next attack（r=-0.445,P=0.038）,but the levels were not correlated with age at onset,number of segments of spinal cord involved,EDSS score,titer of AQP4-Ab（P〉0.05,respectively）.Conclusions The sera hs-CRP in NMO patients are closely related with the disease activity and may indicate the recurrence time.But it can not reflect the severity of the disease.