中文摘要：

目的 探讨长期碘缺乏对子二代大鼠体重、摄食量及食物利用率的影响。方法 依据新疆维吾尔自治区传统碘缺乏病病区居民的膳食模式，以该地区居民的主要食材为原料配制不同碘含量的低碘饲料（碘含量分别为50、20 μg/kg），按随机数字表法将Wistar大鼠随机分为对照组（NI组）、低碘一组（LI组）、低碘二组（LII组），每组给予饲料的碘含量分别为300、50、20 μg/kg。将大鼠作为亲代喂养至其繁殖年龄，生出的子一代大鼠按母鼠组别继续以用相应碘含量的饲料进行喂养，子一代大鼠喂养至繁殖年龄时再进行繁殖得出子二代，子二代大鼠继续按母鼠组别进行喂养，即建立子二代大鼠碘缺乏模型。子二代大鼠喂养至90、180、270日龄时分批处死。采用单因素方差分析对NI、LI、LII组子二代大鼠的体重、摄食量以及食物利用、进行了比较，并对大鼠血清甲状腺激素水平进行了比较。结果 对子二代大鼠一般行为观察发现，LI、LII组大鼠不喜动，反应迟钝，生长发育迟缓，而NI组大鼠表现正常。NI、LI、LII组大鼠喂养至270日龄时，尿碘含量M分别为255.2、1.7、0.2 μg/L，差异有统计学意义（P〈0.001）。NI、LI、LII组雌性大鼠7月龄体重分别为（311.0±2.3）、（288.1±10.5）、（275.7±2.7）g（P〈0.001）；NI、LI、LII组雄性大鼠7月龄体重分别为（517.2±7.8）、（446.0±4.6）、（451.8±19.1）g，差异有统计学意义（P〈0.001）。NI、LI、LII组雌性大鼠7月龄摄食量分别为（499.5±21.8）、（465.0±27.7）、（423.0±13.2）g，差异有统计学意义（P〈0.001）；NI、LI、LII组雄性大鼠摄食量为（760.8±33.0）、（658.4±28.6）、（548.0±18.8）g，差异有统计学意义（P〈0.001）。NI、LI、LII组雌性大鼠7月龄食物利用率分别为（11.7±3.5）%、（8.7±0.4）%、（6.0±0.5）%，差异有统计学意义（P〈0.001）；NI、L

英文摘要：

Objective To study the effect of iodine deficiency on body weight, food consumption, and food utilization rate of second filial generation Wistar rats.Methods According to the food pattern of a high-iodine deficient population, two types of low-iodine food have been produced using the main crops grown in this area （iodine levels of 50 and 20 μg/kg, respectively）. Wistar rats were randomly divided into three groups, normal iodine group （NI group）, low-iodine group one （LI group） and low-iodine group two （LII group）, using the random number table method and fed diets containing 300, 50, and 20 μg/kg of iodine, respectively. Parental generation rats were fed until they reached reproductive age; first filial generation rats were allocated to the same diet as their mothers. After 3 months of feeding, first filial generation rats gave birth to second filial generation rats; second filial generation rats were allocated to the same diet as their mothers. After feeding for 90, 180, and 270 days, rats were sacrificed. One-way analysis of variance was used to analyze body weight, food intake, and food utilization rate data collected during the time of feeding and blood iodine hormone level, which was determined after sacrifice.Results The LI and LII groups generally demonstrated decreased activity, slow reaction, and growth retardation compared with the NI group. After 270 days, the urine iodine levels of the LI and LII groups were 1.7 and 0.2 μg/L, respectively, which were significantly lower than the NI group （255.2 μg/L） （P〈0.001）. Additionally, the weight of female rats in the LI and LII groups were （288.1±10.5） and （275.7±2.7） g, respectively, which was significantly lower than that of the NI group （（311.0±2.3） g） （P〈0.001）. The weight of male rats were （446.0±4.6） and （451.8±19.1） g, respectively, which were significantly lower than that of the NI group （（517.2±7.8） g） （P〈0.001）. In the LI and LII groups, food intake of female and male