中文摘要：

肉毒毒素是自然界中毒性极强的一类神经麻痹毒素,可引起人类和动物肉毒中毒。因其制备简单、毒性强,已被列为最具威胁的生物恐怖剂之一,同时也是重要的毒素战剂。其感染剂量极低,每个人都易感。肉毒中毒后,病情严重者一般2-3 d内即可能死亡。如采取正确及时的治疗,可使肉毒中毒死亡率降低,而快速检测方法的建立无疑是成功治疗的前提。本文就肉毒毒素及其检测方法做一综述。

英文摘要：

Botulinum neurotoxin is a type of neural paralysis toxin of great toxicity known to science and it can cause botulism both in humans and animals. Because of its simple production and potent toxicity, it has been regarded as an inspiration for bioterrorists and it is also the most important toxic warfare agent. The infective dose is rather low and humans are not protected from the toxin. Serious patients may die within 2 to 3 days aider botulism. If timely and correct treatment is taken, the mortality will be decreased and the development of rapid detective methods is thereby the prerequisite to successful treatment. For this reason, the detective method of botulinurn ncurotoxin is always the focus of toxin field. The review makes a general description of botulinum neurotoxin and advances on its detective method.