中文摘要：

目的：检测经前期综合征（PMS）肝气逆、肝气郁证模型大鼠下丘脑及外周血内啡肽（EM）含量变化,观察经前平、经前舒颗粒对PMS肝气逆、肝气郁证的干预作用。方法：以情志刺激多因素法复制PMS肝气逆、郁证大鼠模型,以经前平、经前舒颗粒干预治疗,采用放射免疫法检测模型大鼠下丘脑及血清EM-1、EM-2的含量。结果：与正常组相比,PMS肝气逆证组下丘脑EM-1含量无显著性变化,血清EM-1含量显著上升（P〈0.01）;PMS肝气郁证组下丘脑EM-1含量亦无显著性变化,血清EM-1、EM-2含量显著下降;与模型组相比,经前平组血清EM-1、EM-2含量显著性下降（P〈0.01）,经前舒组血清EM-1、EM-2显著上升。结论：两种病证模型下丘脑EM-1、EM-2的含量变化不明显;PMS肝气逆证大鼠血清EM-1显著性升高,EM-2有上升趋势;PMS肝气郁证大鼠血清EM-1、EM-2含量显著性下降。经前平、经前舒颗粒可分别对外周血中指标的异常变化起到调节作用。

英文摘要：

Objective： To detect the content change of endomorphin （EM） in the hypothalamus and serum of the liver-qi invasion and the liver-qi depression of premenstrual syndrome PMS model rats, and observe the intervention effect of the Jingqianping and Jingqianshu granule. Methods： PM5 model rats with liver-qi invasion were prepared by electric stimulating. PMS model rats with liver-qi depression were prepared by binding the limbs. The content of EM was examined by the radio immunoassay. Results： Compared with the normal group, the content of EM-1 has no significant changes in the hypothalamus, but increased markedly in the serum（P 〈0. 01 ）of PMS model rats with liver-qi invasion, and the content of EM- 1 and EM-2 also have no significant changes in the hypothalamus, hut decreased markedly （P 〈0.01, P 〈 0.05） in the serum of liver-qi depression model rats; the content of EM-1 decreased markedly（P 〈0.0t ） in the serum of Jingqianping granule group; the content of EM-1 and EM-2 increased markedly（P 〈0.01, P 〈 0. 05）in the serum of Jingqianshu granule group. Conclusion： The content of EM-1 ,EM-2 have no significant changes in the hypothalamus of PMS model rats, but increased markedly in the serum of PMS model rats with liver-qi invasion, while decreased significantly in the serum of liver-qi depression model rats, and the two medicine may cure the diseases by regulating the above abnormal changes.