中文摘要：

TET（ten-eleven translocation）蛋白属于酮戊二酸和Fe2＋依赖的双加氧酶,能够产生催化氧化作用。在TET蛋白家族的催化氧化作用下5-甲基胞嘧啶（5-methylcytosine,5mC）可转化为5-羟甲基胞嘧啶（5-hydroxymethylcytosine,5hmC）,并可进一步转化为5-甲酰胞嘧啶（5-formylcytosine,5fC）和5-羧基胞嘧啶（5-carboxylcytosine,5caC）。TET蛋白在DNA胞嘧啶的去甲基化、胚胎发育和基因重新编码等过程都存在重要作用,其中TET蛋白参与DNA胞嘧啶的去甲基化过程的作用机制一直是研究热点,另外,有研究发现TET与肿瘤的发生也存在联系,可能成为新的肿瘤分子标志。

英文摘要：

TET （ten-eleven translocation） proteins belong to alpha-ketoglutaric acid （KG） and Fe^2＋-dependent dioxygenasesin which can catalyze an oxidative process. The 5-methylcytosine （5mC） can be converted to 5-hydroxy-methylcytosine （5hmC） by TET proteins family, and can successively be oxidized to 5-formylcytosine （5fC） and 5-carboxylcytosine （5caC） in DNA. The TET proteins have an important role in DNA de-methylation, embryonic development and reprogramming. The role of TET proteins in DNA de-methylation has been a hot research. Further, studies have found that TET proteins also have an important role in cancer and TET proteins may become a new molecular marker of tumor.