为经由芳基 boronic 酸或酉旨和 TMSCN 的 Cu2O-catalyed 跨 coupling 的芳基 nitriles 的有效、可靠的合成的一个方法被介绍。大量底层装饰了由充满电子、缺乏,位地,很拥挤、易变的功能被容忍。而且,反应能在房间温度在温和条件下面继续。作为催化剂与便宜、容易地可得到、没有卤素的 Cu2O 的使用配对的这些优点为芳基 cyanations 使协议成为一种呼吁的选择。
A method for the efficient and reliable synthesis of aryl nitriles via the Cu20-catalyed cross-coupling of aryl boronic acids or esters and TMSCN is presented. A broad range of substrates decorated by electron-rich and defi- cient, sterically very congested, and labile functionalities were tolerated. Moreover, the reaction can proceed under mild conditions at room temperature. These advantages paired with the use of cheap, readily available, and halo- gen-free Cu20 as catalysts make the protocol an appealing option for aryl cyanations.