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Toxicity of superparamagnetic iron oxide nanoparticles：Research strategies and implications for nanomedicine

ISSN号：1674-1056
期刊名称：《中国物理B：英文版》
时间：0
分类：Q95-33[生物学—动物学] TB383[一般工业技术—材料科学与工程]
作者机构：[1]Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China, [2]Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong 637007, China
相关基金：Project supported by the Major State Basic Research Development Program of China （Grant Nos. 2013CB733802 and 2014CB744503）, the National Natural Science Foundation of China （Grant Nos. 81101101 and 51273165）, the Key Project of Chinese Ministry of Education （Grant No. 212149）, and the Fundamental Research Funds for the Central Universities, China （Grant Nos. 2013121039 and ZK1002）.

关键词：超顺磁性氧化铁, 纳米颗粒, 中毒性, 纳米医学, 生物医学应用, 物理化学性质, 安全问题, 铁纳米粒子, superparamagnetic iron oxide nanoparticle nanotoxicity cytotoxicity oxidative stress reactive oxygen species

中文摘要：

Superparamagnetic iron oxide nanoparticles(SPIONs) are one of the most versatile and safe nanoparticles in a wide variety of biomedical applications. In the past decades, considerable efforts have been made to investigate the potential adverse biological effects and safety issues associated with SPIONs, which is essential for the development of next-generation SPIONs and for continued progress in translational research. In this mini review, we summarize recent developments in toxicity studies on SPIONs, focusing on the relationship between the physicochemical properties of SPIONs and their induced toxic biological responses for a better toxicological understanding of SPIONs.

英文摘要：

Superparamagnetic iron oxide nanoparticles （SPIONs） are one of the most versatile and safe nanoparticles in a wide variety of biomedical applications. In the past decades, considerable efforts have been made to investigate the potential adverse biological effects and safety issues associated with SPIONs, which is essential for the development of next-generation SPIONs and for continued progress in translational research. In this mini review, we summarize recent developments in toxicity studies on SPIONs, focusing on the relationship between the physicochemical properties of SPIONs and their induced toxic biological responses for a better toxicological understanding of SPIONs.

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